Pentobarbital will decrease the level or effect of prednisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will decrease the level or effect of quinine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. When barbiturates like Nembutal are abused, they are not usually the primary drug of abuse. Like https://bookmarksden.com/story20443552/la-guida-definitiva-a-pentobarbital-cosa-%C3%88