If a mum or dad of your proband is known to hold the pathogenic variant discovered within the proband, the danger to your sibs of inheriting the pathogenic variant is 50%. As a result of minimized penetrance, sibs who inherit the pathogenic variant may or may not build aHUS (see https://cristianuqjbr.blogars.com/31259331/how-air-handling-unit-ahu-hire-can-save-you-time-stress-and-money