Co-inhibition of TNKS1/2 by E7449 perhaps enhances the selection and variety of achievable, rationally specific combinations for this therapy. By way of example, a critical function for tankyrase and Wnt/β-catenin signaling was identified for servicing of lung cancer cells for the duration of EGFR inhibition and subsequent inhibition of tankyrase https://davidh421pbu7.wikidirective.com/user